Protein quality control by protease
WebbAbstract The C-terminus of Hsp70 Interacting Protein (CHIP) E3 ligase functions as a key regulator of protein quality control by binding the C-terminal M/IEEVD peptide motif of Hsp/c70 (90) with its N-terminal tetratricopeptide repeat (TPR) domain and facilitating poly ubiquitination of misfolded client proteins via its C-terminal catalytic U-box. WebbThe work by Sun et al. (FEBS J 2024, 10.1111/febs.16757) in this issue focusses on hepsin, a serine protease on the surface of liver and other organs. The authors deduce that spatial positioning of N-glycans on one side of a conserved domain of hepsin, known as the scavenger receptor-rich cysteine domain, regulates calnexin selection for hepsin …
Protein quality control by protease
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WebbCrystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors WebbAbstract Hepatocyte apoptosis is a crucial factor affecting liver quality in brain-dead donors. The identification of key molecular proteins involved in brain-death (BD)-induced hepatocyte apoptosis may help determine an effective method for improving the quality of livers from brain-dead donors.
Webb28 apr. 2015 · Cells therefore rely on a number of protein quality control (PQC) pathways that survey proteins both during and after synthesis to prevent protein aggregation, … Webb26 aug. 2024 · To identify the quality-control pathway (s) that facilitate orphan degradation, we analyzed individual subunits of four diverse multiprotein complexes identified as …
WebbI am a broadly trained cell/molecular biology and biochemistry researcher and educator with expertise in protein quality control and the ubiquitin-proteasome system. My lab … Webb26 sep. 2024 · Cade et al. found that secreted enzymes and enzymes in the pancreatic alkaline pancreatic juice promote digestion and absorption, islet hormones in the acinar maintain glucose homeostasis and regulate protein and fat metabolism [ 11 ]. The pancreas plays a vital role in regulating digestion and nutritional metabolism.
Webb15 okt. 2024 · The major function of the proteasome/Clp protease complex is in protein quality control, through the degradation of misfolded or damaged proteins. However, …
Webb15 nov. 2024 · Instead, the main cellular quality control systems for proteins and organelles, the ubiquitin-proteasome system (UPS) and autophagy, are controlled by … argo oil tankerWebbProtein homeostasis, or proteostasis, has an important regulatory role in cellular function. Protein quality control mechanisms, including protein folding and protein degradation … argon wikipediaWebb15 dec. 2024 · Protein degradation is a crucial cellular process in all-living systems. Here, using Mycoplasma pneumoniae as a model organism, we defined the minimal protein … argo ogden utahWebb23 juli 2024 · Protein mutational landscapes are shaped by the cellular environment, but key factors and their quantitative effects are often unknown. Here we show that Lon, a … balai pelestarian cagar budaya jambiWebbBrief Communication Protease-Mediated Protein Quality Control for Bacterial Acid Resistance Graphical Abstract Highlights d DegP is a key acid protease mediating … argonyx marketingWebbLon plays a key role in protein quality control, degrading misfolded proteins and those not assembled into functional complexes. We propose that regulating complex assembly … balai pelestarian cagar budaya kaltimWebbThe long-term health is inextricably linked to protein quality control. An imbalance in protein homeostasis (proteostasis) can result in severe … argo panel trim baseboard