WebDec 12, 2016 · Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes … WebJul 11, 2024 · The Forkhead box protein M1 (FoxM1) is an appealing target for anti-cancer therapeutics as this cell proliferation-associated transcription factor is overexpressed in most human cancers. FoxM1 is involved in tumor invasion, angiogenesis, and metastasis. To discover novel inhibitors that disrupt the FoxM1-DNA interaction, we identified CDI, a …
Centromere protein U expression promotes non-small-cell lung …
WebNov 4, 2013 · Members of the class O of forkhead box transcription factors (FOXO) have important roles in metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is tightly regulated by posttranslational modification, including phosphorylation, acetylation, and ubiquitylation. Activation of cell survival pathways such … WebMar 15, 2024 · This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008] Other designations. forkhead box protein D3, HNF3/FH transcription factor genesis, autoimmune susceptibility 1. オフィスステーション 年末調整
Elucidating the Possible Role of FoxO in Depression - PubMed
WebThe Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res. 2006;66(4):2153–2161. 24. Kong FF, Qu ZQ, Yuan HH, et al. Overexpression of FOXM1 is associated with EMT and is a predictor of poor prognosis in non-small cell lung cancer. WebApr 4, 2024 · Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to … WebMay 27, 2024 · The subfamily of FOXO transcription factors, including FOXO1 (also known as forkhead in rhabdomyosarcoma), FOXO3 (also known as forkhead in rhabdomyosarcoma-like 1), FOXO4, and FOXO6, is widely expressed in cells and integrates a variety of growth factors, oxidative stress signals, and other stimulatory signals, … オフィスステーション 登録