WebBy using small molecule inhibitors to alter p53 dynamics, we can change the transcriptional program regulated by p53 and thereby control individual cell fates. Our current work … WebJun 15, 2012 · p53 is a tumor suppressor activated in response to cellular stress ( 18, 19 ). Induction of p53 triggers multiple cellular programs ranging from transient responses, such as DNA repair and cell cycle arrest, to terminal fates such as cell death (apoptosis) and permanent cell cycle arrest (senescence) ( Fig. 1A ).
p53 dynamics control cell fate — Experts@Minnesota
WebYang Z, Hanson RL, Batchelor E. Progress and challenges in understanding the regulation and function of p53 dynamics. Biochemical Society Transactions. PMID 34495325 DOI: 10.1042/BST20240148 : 0.696: 2024: Hanson RL, Batchelor E. Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell … WebEric Batchelor, Alexander Loewer, Caroline Mock, Galit Lahav. Research output: Contribution to journal › Article › peer-review. 228 Scopus citations. Overview; ... We quantified the dynamics of p53 in individual cells in response to UV and observed a single pulse that increases in amplitude and duration in proportion to the UV dose. This ... lösenord wifi windows 10
Rucaparib Treatment Alters p53 Oscillations in Single Cells …
WebJared Toettcher, Eric Batchelor, Galit Lahav & Bruce Tidor . Introduction. p53 is a transcription factor involved in cellular stress response, and plays a role in directing the programs of cell cycle arrest, DNA damage repair, and apoptosis. p53 protein levels are seen to undergo a series of pulses after ionizing radiation induced DNA damage. ... WebMar 28, 2024 · Department of Integrative Biology and Physiology Dr. Eric Batchelor awarded new R01 grant Dr. Eric Batchelor awarded new R01 grant Mar 28, 2024 Read Time: 1 minute The Batchelor lab awarded new R01 grant! "The roles of p53 and MYC dynamics in regulating heterogeneous cell fate responses to genotoxic stress." … WebThe Batchelor lab seeks to develop a quantitative, system-level understanding of stress response pathways at multiple scales - from individual cells to whole organisms. Much of their research focuses on cell stress responses mediated by … lose one\u0027s phrase meaning to grow angry